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The epidemiology of convulsive status epilepticus in children: a critical review

Miquel Raspall-Chaure1, Richard F M Chin1, Brian G Neville1

  • 1Neurosciences Unit, UCL - Institute of Child Health, LondonEpilepsy Unit, Great Ormond Street Hospital for Children NHS Trust, LondonThe National Centre for Young People with Epilepsy, LingfieldCentre for Paediatric Epidemiology and Biostatistics, UCL - Institute of Child Health, LondonRadiology and Physics Unit, UCL - Institute of Child Health, London, United Kingdom.

Epilepsia
|July 20, 2007
PubMed

Insights

Childhood convulsive status epilepticus (CSE) incidence varies by age and population factors. Etiology significantly impacts outcomes, but CSE

Area of Science:

  • Neurology
  • Pediatrics
  • Epidemiology

Background:

  • Ongoing debate exists regarding the optimal definition of status epilepticus.
  • The
  • 30-minute definition
  • is widely used for childhood convulsive status epilepticus (CSE).

Purpose of the Study:

  • To analyze the incidence, etiology, and outcomes of childhood CSE.
  • To identify demographic and clinical factors influencing CSE epidemiology and prognosis.

Main Methods:

  • Retrospective analysis of childhood CSE cases.
  • Examination of incidence rates based on age, socioeconomic, and ethnic factors.

Main Results:

  • CSE incidence is approximately 20/100,000/year in developed countries, highest in the first year of life.
  • Febrile seizures are the most common cause; 40% of children have prior neurological abnormalities.
  • Outcome is primarily determined by etiology, with unknown influence of age or duration on CSE's role in secondary epilepsy.

Conclusions:

  • Childhood CSE epidemiology is age-dependent, with distinct patterns in infants versus older children.
  • Further research is needed to understand CSE's causative role in mesial temporal sclerosis and epilepsy.
  • Identifying ethnic, genetic, and socioeconomic factors is crucial for CSE prevention strategies.

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