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Related Experiment Videos

Nickel allergy: relationship between patch test and repeated open application test thresholds.

L A Fischer1, J D Johansen, T Menné

  • 1The National Allergy Research Centre, Department of Dermatology, University of Copenhagen, Gentofte Hospital, Ledreborg Allé 40, 2820 Gentofte, Denmark. larupf@yahoo.dk

The British Journal of Dermatology
|July 20, 2007
PubMed
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The patch test has a higher nickel allergy elicitation threshold than the repeated open application test (ROAT) per application. However, the accumulated ROAT dose threshold is similar to the patch test, aiding risk assessment.

Area of Science:

  • Dermatology
  • Allergology
  • Toxicology

Background:

  • Nickel allergy prevalence varies globally.
  • Exposure regulations effectively reduce nickel allergy frequency.
  • Patch test reactivity correlates with repeated open application test (ROAT) reactivity.

Purpose of the Study:

  • Determine nickel allergy elicitation thresholds using patch tests and ROAT.
  • Compare thresholds obtained from patch tests versus ROAT.
  • Evaluate dose-response relationships in nickel-allergic individuals.

Main Methods:

  • Twenty nickel-allergic individuals underwent patch testing with 19 concentrations.
  • The same participants were tested with ROAT using three concentrations for up to 21 days.
  • Eighteen non-allergic individuals served as controls for ROAT.

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Main Results:

  • The predicted elicitation dose for 10% of allergic individuals was 0.78 µg nickel/cm² in patch tests.
  • ROAT elicitation threshold per application was significantly lower than patch test threshold.
  • Accumulated ROAT dose thresholds at 1, 2, and 3 weeks showed no significant difference from patch test dose-response.

Conclusions:

  • Patch test elicitation threshold for nickel allergy is higher than ROAT per application.
  • Accumulated ROAT elicitation threshold is comparable to the patch test threshold.
  • Findings are crucial for risk assessment using dose-response data from allergic patients.