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Published on: July 21, 2023
Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms
Guy M Lenk1, Gerard Tromp, Shantel Weinsheimer
1Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA. glenk@med.wayne.edu <glenk@med.wayne.edu>
Background:
Abdominal aortic aneurysms are a common disorder with an incompletely understood etiology. We used Illumina and Affymetrix microarray platforms to generate global gene expression profiles for both aneurysmal (AAA) and non-aneurysmal abdominal aorta, and identified genes that were significantly differentially expressed between cases and controls.
Results:
Affymetrix and Illumina arrays included 18,057 genes in common; 11,542 (64%) of these genes were considered to be expressed in either aneurysmal or normal abdominal aorta. There were 3,274 differentially expressed genes with a false discovery rate (FDR)
Conclusion:
Previous studies have provided evidence for the involvement of the immune system in AAA. The current expression analysis extends these findings by demonstrating broad coordinate gene expression in immunological pathways. A large number of genes involved in immune function were differentially expressed in AAA, and the pathway analysis gave these results a biological context. The data provide valuable insight for future studies to dissect the pathogenesis of human AAA. These pathways might also be used as targets for the development of therapeutic agents for AAA.
