Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
X-ray Imaging01:24

X-ray Imaging

German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with X-rays, and by 1900, X-ray was widely...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Photon counting spectral CT component analysis of coronary artery atherosclerotic plaque samples.

The British journal of radiology·2014
Same author

Adaptive two-pass cone-beam artifact correction using a FOV-preserving two-source geometry: a simulation study.

Medical physics·2009
Same author

Cramér-Rao lower bound of basis image noise in multiple-energy x-ray imaging.

Physics in medicine and biology·2009
Same author

Experimental feasibility of multi-energy photon-counting K-edge imaging in pre-clinical computed tomography.

Physics in medicine and biology·2008
Same author

Noise and resolution in images reconstructed with FBP and OSC algorithms for CT.

Medical physics·2007
Same author

Cardiac cone-beam CT volume reconstruction using ART.

Medical physics·2005

Related Experiment Video

Updated: Jul 13, 2026

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
07:48

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

Published on: September 30, 2022

K-edge imaging in x-ray computed tomography using multi-bin photon counting detectors.

E Roessl1, R Proksa

  • 1Philips Research Europe, Sector Medical Imaging Systems, Hamburg, Germany. ewald.roessl@philips.com

Physics in Medicine and Biology
|July 20, 2007
PubMed
Summary

Energy-sensitive photon counting detectors reveal elemental composition from X-ray spectra. This technology enables enhanced imaging of high atomic number elements, like gadolinium contrast agents, improving differentiation in medical scans.

More Related Videos

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
08:30

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

Published on: September 11, 2011

Energy Dispersive X-ray Tomography for 3D Elemental Mapping of Individual Nanoparticles
10:00

Energy Dispersive X-ray Tomography for 3D Elemental Mapping of Individual Nanoparticles

Published on: July 5, 2016

Related Experiment Videos

Last Updated: Jul 13, 2026

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
07:48

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

Published on: September 30, 2022

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging
08:30

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

Published on: September 11, 2011

Energy Dispersive X-ray Tomography for 3D Elemental Mapping of Individual Nanoparticles
10:00

Energy Dispersive X-ray Tomography for 3D Elemental Mapping of Individual Nanoparticles

Published on: July 5, 2016

Area of Science:

  • Medical Imaging
  • Photon Counting Detectors
  • X-ray Spectroscopy

Background:

  • Conventional X-ray and CT systems integrate X-ray energy, losing spectral information crucial for elemental composition analysis.
  • Existing systems are insensitive to energy spectrum changes after X-ray passage through matter.

Purpose of the Study:

  • To evaluate the capability of energy-sensitive photon counting detectors to extract quantitative elemental composition information from X-ray spectra.
  • To investigate the detection of K-edge discontinuities for elemental analysis.
  • To measure and image gadolinium-based contrast agent density using generalized dual-energy pre-processing.

Main Methods:

  • Utilizing energy-sensitive photon counting detectors operating in pulse-mode.
  • Focusing on element-specific K-edge discontinuities in the photo-electric cross-section.
  • Employing generalized dual-energy pre-processing techniques.
  • Simulating images of atherosclerotic coronary vessels with gadolinium contrast agents.

Main Results:

  • Photon counting detectors can reveal quantitative information about absorber elemental composition.
  • Successful detection of element-specific K-edge discontinuities.
  • Demonstrated ability to measure and image local density of gadolinium contrast agents.
  • Simulated images show improved contrast between plaque and contrast agent compared to conventional systems.

Conclusions:

  • Energy-sensitive photon counting X-ray systems offer new possibilities for imaging high atomic number elements in the human body.
  • This technology enhances differentiation between tissues and contrast agents, outperforming conventional integrating detectors.
  • The spectral information processing is crucial for accurate elemental imaging.