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Biomimetic apatite coatings on titanium coprecipitated with cephradine and salviae miltlorrhizae
Zhoujun Wu1, Bo Feng, Jie Weng
1Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.
Abstract:
Incorporation of antibiotics in the apatite coatings on titanium surface is an effective step for surgical infections of titanium implant. In this work, antibiotics cephradine and traditional Chinese medicine salviae miltlorrhizae (SM) were incorporated in the simulated body fluid (SBF). The apatite coatings were coprecipitated with cephradine and SM by a biomimetic method. The research showed that in the biomimetic coprecipitation process cephradine containing carboxylic groups were beneficial to the apatite coprecipitation. X-ray diffraction patterns showed that cephradine had a positive effect on the crystal growth in terms of cystallinity. And also in the Fourier transformed infrared spectra, the organic groups corresponded with cephradine were also observed. However, little apatite formed on the titanium immersed in SBF with SM. Probably, SM was more absorbed on the surface when calcium and phosphate ions precipitated.
Insights
Cephradine enhanced apatite coating formation on titanium implants, improving crystallinity for surgical infection prevention. Salvia miltiorrhizae showed limited apatite formation, suggesting surface absorption interference.
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Nanotechnology
Background:
- Surgical site infections are a major complication of titanium implants.
- Apatite coatings on titanium can improve osseointegration and deliver therapeutic agents.
- Incorporating antibiotics or traditional medicines into coatings offers a strategy to combat infections.
Purpose of the Study:
- To investigate the effect of cephradine and Salvia miltiorrhizae (SM) on biomimetic apatite coating formation on titanium.
- To evaluate the influence of these agents on the structural and crystalline properties of the apatite coatings.
Main Methods:
- Biomimetic coprecipitation of apatite coatings in simulated body fluid (SBF) containing cephradine and SM.
- Analysis of apatite coating formation using X-ray diffraction (XRD) and Fourier-transformed infrared spectroscopy (FTIR).
Main Results:
- Cephradine, with its carboxylic groups, promoted apatite coprecipitation and enhanced crystal growth and crystallinity.
- FTIR confirmed the presence of cephradine within the apatite coatings.
- Minimal apatite formation was observed with SM, likely due to its adsorption onto the titanium surface, hindering ion precipitation.
Conclusions:
- Cephradine is beneficial for biomimetic apatite coating formation on titanium, improving coating quality and potentially aiding in infection prevention.
- SM's inhibitory effect on apatite formation suggests it may not be suitable for this biomimetic coating method.
- This study highlights the differential impact of incorporated agents on apatite coating development for biomedical applications.
