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Updated: Jul 13, 2026
10:12
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
Cell-penetrating peptides in drug development: enabling intracellular targets
1KAI Pharmaceuticals Inc., 270 Littlefield Avenue, South San Francisco, CA 94080, USA.
Biochemical Society Transactions
|July 20, 2007
Summary
Cell-penetrating peptides (CPPs) can deliver large molecules into cells, aiding drug discovery. Further research into CPP properties is needed for developing effective CPP-drug therapeutics.
Area of Science:
- Biochemistry
- Molecular Biology
- Pharmacology
Background:
- Cell-penetrating peptides (CPPs) facilitate the transport of macromolecules across cell membranes.
- CPPs offer a method to target intracellular molecules, overcoming cellular entry barriers.
- Their potential in drug discovery for validating intracellular targets is recognized.
Purpose of the Study:
- To explore the potential of CPP-drug conjugates as human therapeutic agents.
- To identify key CPP characteristics essential for successful drug development.
- To discuss critical areas for developing CPP-conjugated compounds as therapeutics.
Main Methods:
- Literature review on CPP capabilities and drug development considerations.
- Discussion of in vivo pharmacology, pharmacokinetics, pharmacodynamics, and safety of CPPs.
- Analysis of CPP properties relevant to therapeutic applications.
Main Results:
- CPPs can penetrate diverse tissues and enable intracellular target modulation.
- Limited knowledge exists regarding CPP characteristics crucial for drug development.
- Understanding CPP in vivo properties is vital for advancing CPP-based therapeutics.
Conclusions:
- CPPs hold significant promise for drug discovery by enabling intracellular delivery.
- Further investigation into CPP properties is necessary to optimize their use in therapeutic drug development.
- CPP-drug conjugates represent a promising avenue for novel therapeutic strategies.
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