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Identification of novel phencyclidine metabolites formed in vitro by rabbit microsomal metabolism
R Herber1, R Perrin, J M Ziegler
1URA, CNRS no. 597, Centre du Médicament, Nancy, France.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
|November 1, 1991
Abstract:
1. Phencyclidine (PCP) was incubated with rabbit liver and brain microsomal fractions, and the structures of metabolites formed by oxidation determined by g.l.c.-mass spectrometry. 2. The formation of several known mono- and di-hydroxylated metabolites, as well as two new metabolites, was seen in the liver preparations. 3. Hydroxylated PCP metabolites were also formed after incubation of PCP with brain microsomes, indicating that PCP biotransformation may occur in the brain itself.