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Related Experiment Videos

Naproxen-induced recurrent aseptic meningitis.

B B Weksler1, A M Lehany

  • 1Department of Medicine, Cornell University Medical College, New York, NY 10021.

DICP : the Annals of Pharmacotherapy
|November 1, 1991
PubMed
Summary
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Recurrent aseptic meningitis was linked to naproxen use in a patient with systemic lupus erythematosus (SLE). Stopping naproxen resolved the meningitis, highlighting NSAIDs as potential causes for unexplained meningitis.

Area of Science:

  • Neurology
  • Rheumatology
  • Pharmacology

Background:

  • Aseptic meningitis is associated with nonsteroidal anti-inflammatory drugs (NSAIDs), especially in immunocompromised individuals.
  • Naproxen has rarely been implicated in causing meningitis.

Observation:

  • A 38-year-old woman with systemic lupus erythematosus (SLE) developed recurrent aseptic meningitis.
  • Episodes correlated with naproxen initiation or dosage increases, with no signs of SLE flare.

Findings:

  • Discontinuation of naproxen led to rapid symptom resolution.
  • The patient remained meningitis-free for over 18 months after stopping naproxen.

Implications:

  • Naproxen can cause recurrent aseptic meningitis, particularly in patients with underlying autoimmune conditions like SLE.

Related Experiment Videos

  • NSAIDs should be considered in the differential diagnosis of meningitis with unknown causes.