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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent

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Lactate quantification by proton magnetic resonance spectroscopy using a clinical MRI machine: a basic study.

T Isobe¹, A Matsumura, I Anno

¹School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan. tiso@kitasato-u.ac.jp

Australasian Radiology

|July 20, 2007

Summary

This study developed a reliable proton magnetic resonance spectroscopy (MRS) method for quantifying lactate concentration using a 1.5-T MRI. The method accurately measured lactate in phantoms and a patient with MELAS.

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Area of Science:

Biomedical Imaging
Metabolic Disorders
Spectroscopy

Background:

Lactate accumulation is a key indicator of metabolic dysfunction.
Accurate quantification of lactate is crucial for diagnosing and monitoring various diseases.
Proton magnetic resonance spectroscopy (MRS) offers a non-invasive method for in vivo metabolite quantification.

Purpose of the Study:

To establish a reliable quantification method for lactate concentration using proton MRS on a conventional 1.5-T MRI scanner.
To validate the method using a lactate phantom with known concentrations.
To demonstrate the clinical applicability of the method in a patient with MELAS.

Main Methods:

Proton MRS was performed on a 1.5-T MRI system using point resolved spectroscopy.
Lactate phantoms with concentrations ranging from 1 to 14 mmol/L were analyzed.
T2 relaxation time was calculated using specific echo times, and tissue water served as an internal standard for quantification.

Main Results:

A strong correlation (R=0.99) was observed between calculated and known lactate concentrations in phantoms.
The established method demonstrated high accuracy with a constant factor of 0.32.
In a patient with MELAS, MRS measured a lactate concentration of 6.2 mmol/kg wet weight, consistent with previous findings.

Conclusions:

A reliable method for lactate quantification by proton MRS on a 1.5-T MRI has been successfully established.
The method is validated by phantom studies and shows promise for clinical applications.
This technique can aid in the diagnosis and management of conditions associated with lactate accumulation, such as MELAS.