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Clindamycin and taste disorders.

Mark C H de Groot1, Eugène P van Puijenbroek

  • 1Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, The Netherlands. m.degroot@lareb.nl

British Journal of Clinical Pharmacology
|July 20, 2007
PubMed
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Clindamycin use can cause taste disorders, with reports suggesting a link independent of patient factors. This adverse drug reaction may involve clindamycin concentrations in bodily fluids like saliva.

Area of Science:

  • Pharmacovigilance
  • Adverse Drug Reactions
  • Clinical Pharmacology

Background:

  • Topical clindamycin is linked to taste disturbances, but the reaction's nature is poorly understood.
  • Limited data exists on clindamycin-induced taste disorders.

Purpose of the Study:

  • To characterize clindamycin-induced taste disorders.
  • To analyze factors contributing to this adverse drug reaction.

Main Methods:

  • Searched the Netherlands Pharmacovigilance Centre database for antibiotic-related taste disorders.
  • Performed clinical review and logistic regression analysis.
  • Compared patient demographics and clindamycin formulations against other antibiotic users.

Main Results:

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  • Taste disorders were reported in 18% of clindamycin cases.
  • Oral and intravenous formulations were implicated; latency was often less than one day.
  • Disproportionality analysis indicated a possible causal relationship (OR 7.0).

Conclusions:

  • A link between clindamycin and taste disorders is supported by statistical analysis.
  • The association appears independent of age, gender, and infection type.
  • Clindamycin concentrations in saliva may play a role.