Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 13, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Endodermal sinus tumor diagnosed in pregnancy: a case report.

H Robova1, L Rob, M Hrehorcak

  • 1Department of Obstetrics and Gynecology, Faculty Hospital Motol, 2nd Medical Faculty, Charles University Prague, Prague, Czech Republic. helena.robova@lfmotol.cuni.cz

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
|July 20, 2007
PubMed
Summary

Pure endodermal sinus tumors (ESTs) in pregnancy are rare but treatable. Adjuvant chemotherapy, including cisplatin monotherapy during gestation, offers a good prognosis for both mother and child.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinically relevant histopathological features and biomarkers in endometrial cancer.

Ceska gynekologie·2026
Same author

Analysis of metalothionein in patients with malignant liver tumors.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2024
Same author

ENGOT-en11/GOG-3053/KEYNOTE-B21: a randomised, double-blind, phase III study of pembrolizumab or placebo plus adjuvant chemotherapy with or without radiotherapy in patients with newly diagnosed, high-risk endometrial cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

Staging for endometrial carcinoma FIGO 2023 and its relevance for clinical practice.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2024
Same author

Human papillomavirus infection (HPV) and pregnancy.

Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne·2024
Same author

Anatomy of the pudendal nerve in clinically important areas: a pictorial essay and narrative review.

Surgical and radiologic anatomy : SRA·2024

Area of Science:

  • Gynecologic Oncology
  • Reproductive Medicine
  • Maternal-Fetal Medicine

Background:

  • Endodermal sinus tumor (EST) is a rare ovarian germ cell tumor with rapid growth.
  • Occurrence of EST during pregnancy is exceptionally uncommon.

Observation:

  • A 34-year-old pregnant patient was diagnosed with stage IC EST at 22 weeks gestation.
  • Treatment involved four cycles of cisplatin monotherapy followed by three cycles of combination chemotherapy (cisplatin, bleomycin, etoposide) during pregnancy.
  • The patient achieved complete remission 28 months post-treatment, maintaining good health.

Findings:

  • A healthy infant was delivered via cesarean section at 35 weeks gestation.
  • The infant exhibited normal development and examinations during the first two years of life.

Related Experiment Videos

Last Updated: Jul 13, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

  • Cisplatin monotherapy demonstrated effectiveness and safety during pregnancy.

    • Implications:

    • Adjuvant therapy significantly improves the prognosis for ovarian endodermal sinus tumors.
    • Cisplatin-based chemotherapy can be a viable and safe treatment option for EST during pregnancy.
    • This case highlights successful management of a rare gestational malignancy, ensuring positive maternal and fetal outcomes.