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Related Experiment Video

Updated: Jul 13, 2026

Using Flow Cytometry to Detect and Quantitate Altered Blood Formation in the Developing Zebrafish
07:32

Using Flow Cytometry to Detect and Quantitate Altered Blood Formation in the Developing Zebrafish

Published on: April 29, 2021

Zebrafish: from hematology to hydrology.

P Jagadeeswaran1, V Kulkarni, M Carrillo

  • 1Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA. jag@unt.edu

Journal of Thrombosis and Haemostasis : JTH
|August 1, 2007
PubMed
Summary

Zebrafish models reveal conserved mechanisms of hemostasis and thrombosis. Researchers identified novel proteases in fish blood that may be relevant to human bleeding and clotting disorders.

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Generation and use of recombinant gonadotropins in fish.

General and comparative endocrinology·2020

Area of Science:

  • Comparative biology
  • Genetics
  • Physiology

Background:

  • Hemostasis is a critical defense against bleeding, but abnormal hemostasis causes bleeding disorders and thrombosis.
  • While mammalian hemostasis is well-studied, many factors remain unidentified.
  • Classical genetics has limitations in fully elucidating complex pathways like hemostasis.

Purpose of the Study:

  • To establish zebrafish as a model for studying hemostasis and thrombosis using classical genetics.
  • To develop and utilize screening tools for identifying hemostatic mutants.
  • To investigate novel aspects of thrombus formation and identify new hemostatic factors.

Main Methods:

  • Utilized classical genetic approaches in zebrafish.
  • Developed specific screening tools for isolating hemostatic mutants.

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Repeated Blood Collection for Blood Tests in Adult Zebrafish
06:17

Repeated Blood Collection for Blood Tests in Adult Zebrafish

Published on: August 30, 2015

Flat Mount Preparation for Observation and Analysis of Zebrafish Embryo Specimens Stained by Whole Mount In situ Hybridization
06:36

Flat Mount Preparation for Observation and Analysis of Zebrafish Embryo Specimens Stained by Whole Mount In situ Hybridization

Published on: July 17, 2014

Related Experiment Videos

Last Updated: Jul 13, 2026

Using Flow Cytometry to Detect and Quantitate Altered Blood Formation in the Developing Zebrafish
07:32

Using Flow Cytometry to Detect and Quantitate Altered Blood Formation in the Developing Zebrafish

Published on: April 29, 2021

Repeated Blood Collection for Blood Tests in Adult Zebrafish
06:17

Repeated Blood Collection for Blood Tests in Adult Zebrafish

Published on: August 30, 2015

Flat Mount Preparation for Observation and Analysis of Zebrafish Embryo Specimens Stained by Whole Mount In situ Hybridization
06:36

Flat Mount Preparation for Observation and Analysis of Zebrafish Embryo Specimens Stained by Whole Mount In situ Hybridization

Published on: July 17, 2014

  • Employed knockdown methods to study gene function in hemostasis.
  • Characterized thrombus formation physiology.

    • Main Results:

    • Confirmed essential similarity between zebrafish and mammalian hemostasis.
    • Successfully identified hemostatic mutants and characterized thrombocyte clustering.
    • Discovered fish-specific proteases involved in hemostasis with potential human relevance.

    Conclusions:

    • Zebrafish are a viable model for genetic studies of hemostasis and thrombosis.
    • Novel factors, including secreted proteases, contribute to hemostasis.
    • Further research is ongoing to identify all components of thrombus formation.