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Related Experiment Video

Updated: Jul 13, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Published on: December 9, 2022

Venous thrombosis in the elderly.

F R Rosendaal¹, A VAN Hylckama Vlieg, C J M Doggen

¹Department of Clinical Epidemiology and Hematology, Leiden University Medical Center, Leiden, The Netherlands. f.r.rosendaal@lumc.nl

Journal of Thrombosis and Haemostasis : JTH

|August 1, 2007

Summary

Elderly individuals face a higher risk of venous thrombosis and bleeding during anticoagulant therapy. Research indicates both environmental factors and coagulation system abnormalities contribute significantly to thrombosis in older adults.

Related Experiment Videos

Last Updated: Jul 13, 2026

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Published on: December 9, 2022

Area of Science:

Gerontology
Hematology
Thrombosis Research

Background:

Venous thrombosis incidence is 1-2 per 1000 person-years overall, but approaches 1% annually in the very elderly.
The elderly with thrombosis exhibit high case-fatality rates, exacerbated by cancer and age-dependent risks of major hemorrhage during anticoagulation.
Despite increased vulnerability, research on venous thrombosis etiology and treatment in the elderly is less extensive compared to younger populations.

Purpose of the Study:

To review the current understanding of venous thrombosis in the elderly.
To highlight the roles of environmental factors and coagulation system abnormalities in geriatric thrombosis.
To emphasize the need for increased research focus on thrombosis in older adults.

Main Methods:

Comprehensive literature review on venous thrombosis in the elderly.
Analysis of new data from the MEGA-study.
Discussion of etiological factors including environmental risks and coagulation system abnormalities.

Main Results:

Environmental risk factors like immobilization and cancer are significant contributors to thrombosis in the elderly.
Abnormalities within the coagulation system are equally or more critical in causing thrombosis in older individuals compared to younger ones.
The risk of major hemorrhage during anticoagulant therapy is strongly age-dependent, increasing elderly patient vulnerability.

Conclusions:

Thrombosis in the elderly is a critical issue influenced by both external factors and intrinsic coagulation system changes.
Further research specifically targeting the elderly population is essential for improving the diagnosis and management of venous thrombosis.
Future studies should prioritize understanding and addressing the unique aspects of thrombosis in older adults.