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Related Experiment Video

Updated: Jul 13, 2026

Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis
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Autoimmune prostatitis: state of the art.

R D Motrich1, M Maccioni, C M Riera

  • 1Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba, Argentina.

Scandinavian Journal of Immunology
|July 20, 2007
PubMed
Summary

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) may involve an autoimmune response against prostate antigens. Rodent models of experimental autoimmune prostatitis (EAP) help study this condition and its immune mechanisms.

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Area of Science:

  • Urology
  • Immunology
  • Pathology

Background:

  • Prostate diseases affect men of all ages, with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) being highly prevalent, especially in younger men.
  • CP/CPPS etiology remains largely unknown, but autoimmune responses targeting prostate antigens are implicated in a significant patient subset.
  • Understanding CP/CPPS is crucial due to its prevalence and impact on urologic health.

Purpose of the Study:

  • To review current knowledge on rodent models of experimental autoimmune prostatitis (EAP).
  • To summarize immunological alterations observed in CP/CPPS patients.
  • To discuss the utility of EAP models in studying human CP/CPPS.

Main Methods:

  • Review of literature on rodent models of experimental autoimmune prostatitis (EAP).

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  • Analysis of immunological findings in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
  • Comparison of EAP models with human disease characteristics.

    • Main Results:

    • Tolerance to prostate antigens can be broken in specific rat and mouse strains, eliciting cellular and humoral immune responses.
    • A Th1 immune response pattern is typically observed, with cellular infiltration driving prostate lesions.
    • Genetic background and hormonal factors may predispose young males to autoimmune prostatitis, which can also occur spontaneously in older susceptible strains.

    Conclusions:

    • Rodent models of EAP provide valuable insights into the autoimmune mechanisms underlying CP/CPPS.
    • Immune cell infiltration and Th1 responses are key pathogenic features.
    • EAP models serve as relevant tools for investigating human prostate autoimmune diseases.