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Hyperhomocysteinemia and central retinal vein occlusion in Iranian population

Sasan Moghimi1, Zahra Najmi, Hooshang Faghihi

  • 1Farabi Eye Research Center, Department of Ophthalmology, Tehran University of Medical Sciences, Quazvin Square, Tehran 1336616351, Iran. sasanimii@yahoo.com

International Ophthalmology
|July 20, 2007
PubMed

Insights

Elevated total plasma homocysteine is an independent risk factor for central retinal vein occlusion (CRVO) in Iranians. Measuring homocysteine levels may aid in CRVO diagnosis and management.

Area of Science:

  • Ophthalmology
  • Cardiovascular Science
  • Clinical Biochemistry

Background:

  • Central retinal vein occlusion (CRVO) is a significant cause of vision loss.
  • Hyperhomocysteinemia, an elevation in plasma homocysteine, is a potential risk factor for vascular diseases.

Purpose of the Study:

  • To assess total plasma homocysteine levels in Iranian patients during the acute phase of CRVO.
  • To determine if hyperhomocysteinemia is a risk factor for CRVO in this population.

Main Methods:

  • A case-control study involving 54 patients with newly diagnosed CRVO and 51 matched controls.
  • Fasting total plasma homocysteine levels were measured and compared between groups.

Main Results:

  • Patients with CRVO had significantly higher mean total plasma homocysteine levels (14.76±7.67 µmol/l) compared to controls (11.42±3.74 µmol/l).
  • Hyperhomocysteinemia was associated with an increased odds ratio for CRVO (OR=2.88, P=0.03), and levels above 15 µmol/l showed a higher adjusted odds ratio (OR=4.71, P=0.009).
  • No significant difference in hyperhomocysteinemia prevalence was observed across different age groups.

Conclusions:

  • Elevated total plasma homocysteine is an independent risk factor for CRVO in the Iranian population.
  • Measuring total homocysteine levels should be considered in the initial evaluation and management of CRVO patients, alongside conventional cardiovascular risk factors.
Abstract

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