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Development of acute morphine tolerance in peripheral clinico-chemical parameters
1Central Laboratory, Markusovszky Teaching Hospital, Szombathely, Hungary.
Acta Physiologica Hungarica
|January 1, 1991
Abstract:
Changes in peripheral clinico-chemical parameters packed cell volume (PCV), hemoglobin (HGB), serum glucose, carbamide-nitrogen (CN), and creatinine were investigated in mice during the development of acute morphine tolerance. Acute morphine treatment (in drug-naive organism) altered the PCV, HGB, serum glucose and CN levels in a naloxone-reversible manner. Acute tolerance developed in PCV, HGB and CN values. The data raise the possibility of a relationship between clinico-chemical and pharmacological tolerance.