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Published on: September 16, 2021
WITHDRAWN: Bromocriptine for unexplained subfertility in women
E Hughes1, J Collins, P Vandekerckhove
1McMaster University, Rm HSC-4F7, Dept of Obstetrics & Gynecol, 1200 Main St West, Hamilton, Ontario, Canada, L8N 3Z5. hughese@mcmaster.ca
Background:
Bromocriptine improves hyperprolactinemic amenorrhea and so could also be helpful in the treatment of unexplained subfertility in women.
Objectives:
To assess the effects of bromocriptine in women with unexplained subfertility.
Search Strategy:
The Cochrane Subfertility Review Group specialised register of controlled trials was searched.
Selection Criteria:
Randomised trials comparing bromocriptine with placebo or no treatment in women with unexplained subfertility.
Data Collection And Analysis:
Two reviewers applied the eligibility criteria and assessed trial quality independently.
Main Results:
Three trials involving of 127 women were included. All trials were double-blind comparisons with placebo, and one was of crossover design. Conception rates with bromocriptine treatment did not improve compared with placebo (odds ratio was 1.12, 95% confidence interval 0.48 to 2.57).
Authors' Conclusions:
There is not enough evidence to evaluate bromocriptine use in women with unexplained subfertility. However trials for women with unexplained subfertility who also have expressible galactorrhea may be worthwhile.
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