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WITHDRAWN: Prophylactic corticosteroids for preterm birth.

P Crowley1

  • 1Trinity College Dublin, Department of Obstetrics and Gynaecology, Coombe Women's Hospital, Dublin 8, Ireland. patc@indigo.ie

The Cochrane Database of Systematic Reviews
|July 20, 2007
PubMed
Summary
This summary is machine-generated.

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Antenatal corticosteroids significantly reduce mortality and respiratory distress syndrome in preterm infants. These benefits are observed across various gestational ages and do not have identified adverse effects.

Area of Science:

  • Obstetrics and Gynecology
  • Neonatology
  • Pharmacology

Background:

  • Respiratory distress syndrome (RDS) is a major complication of prematurity.
  • RDS leads to significant mortality and long-term morbidity in neonates.

Purpose of the Study:

  • To review the efficacy of antenatal corticosteroids for accelerating fetal lung maturity.
  • To assess the impact of corticosteroids on preterm delivery outcomes.

Main Methods:

  • Systematic review of randomized and quasi-randomized trials.
  • Included trials compared corticosteroids with placebo or no treatment in women at risk of preterm delivery.

Main Results:

  • Corticosteroids (betamethasone, dexamethasone, hydrocortisone) significantly reduced neonatal mortality (OR 0.60) and RDS (OR 0.53).

Related Experiment Videos

  • Benefits were consistent across gestational ages, gender, and race.
  • No adverse consequences of prophylactic corticosteroid use were identified.

    • Conclusions:

    • Antenatal corticosteroids are effective in preventing RDS and neonatal mortality in preterm infants.
    • Further evidence is needed to assess the safety and efficacy of repeated corticosteroid doses in women at ongoing risk of preterm birth.