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Updated: Jul 13, 2026
04:53
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
WITHDRAWN: High protein supplementation in pregnancy
1McGill University, Faculty of Medicine, 1020 Pine Avenue West, Montreal, Quebec, Canada, H3A 1A2. michael.kramer@mcgill.ca
The Cochrane Database of Systematic Reviews
|July 20, 2007
Summary
High-protein nutritional supplements during pregnancy did not demonstrate clear benefits for fetal growth or pregnancy outcomes. More research is needed to evaluate their effectiveness and safety for pregnant women.
Area of Science:
- Obstetrics and Gynecology
- Nutritional Science
- Perinatal Medicine
Background:
- Nutritional supplementation in pregnancy is crucial for maternal and fetal well-being.
- High-protein supplements are sometimes considered to support fetal growth and prevent adverse pregnancy outcomes.
Purpose of the Study:
- To evaluate the impact of high-protein nutritional supplements on pregnant women.
- Assessed effects on gestational weight gain, fetal growth, gestational duration, and maternal/fetal morbidity and mortality.
Main Methods:
- Systematic review of controlled trials from the Cochrane Pregnancy and Childbirth Group register.
- Included studies where protein provided >25% of supplement energy.
- Data extracted from published reports and trialist communications.
Main Results:
- Two trials with 1076 women were analyzed.
- No significant improvement in fetal growth was observed; a slight decrease in birth weight was noted (-58.4 g).
- A nonsignificant increase in neonatal death risk was reported in one trial.
Conclusions:
- Current evidence is insufficient to support or refute the use of high-protein supplementation in pregnancy.
- Further research is required to determine the efficacy and safety of these supplements.
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