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Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...

Hormonal Regulation of the Menstrual Cycle

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The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
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Ovarian Cycle

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The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...

Oogenesis

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Related Experiment Video

Updated: Jul 13, 2026

Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma

Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma

Published on: January 22, 2022

Ovulation suppression for endometriosis.

E Hughes¹, J Brown, J J Collins

¹McMaster University, Department of Obstetrics and Gynaecology, 1200 Main St West, Room HSC-4F7, Hamilton, Ontario, Canada L8N 3Z5. hughese@mcmaster.ca

The Cochrane Database of Systematic Reviews

|July 20, 2007

Summary

Ovulation suppression agents do not improve pregnancy rates for women with endometriosis-associated subfertility. This systematic review found no evidence of benefit from treatments like danazol, progestins, or oral contraceptives for conception.

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Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis

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Last Updated: Jul 13, 2026

Surgical Techniques to Optimize Ovarian Reserve during Laparoscopic Cystectomy for Ovarian Endometrioma

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Published on: January 22, 2022

Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis

Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis

Published on: February 26, 2019

Area of Science:

Reproductive Medicine
Gynecology
Infertility Research

Background:

Endometriosis is characterized by endometrial tissue outside the uterus and is estrogen-dependent.
This hormonal link has led to the use of ovulation suppression agents to enhance fertility.

Purpose of the Study:

To evaluate the efficacy of ovulation suppression agents in treating endometriosis-related subfertility.
To assess improvements in pregnancy and live birth outcomes.

Main Methods:

Systematic review of randomized controlled trials (RCTs) comparing ovulation suppression agents with placebo, no treatment, or other agents.
Searched multiple databases including Cochrane, MEDLINE, and EMBASE up to October 2007.
Data extraction and quality assessment by independent reviewers; meta-analysis using odds ratios.

Main Results:

Twenty-four RCTs were included. Ovulation suppression showed no significant benefit over placebo or no treatment for pregnancy rates (OR 0.79-0.80).
Compared to danazol, gonadotropin-releasing hormone agonists (GnRHAs) showed a benefit for pregnancy (OR 1.45-1.63), but GnRHAs were not superior to oral contraceptives.
Statistical heterogeneity was low across all analyses (I²=0%).

Conclusions:

Current evidence does not support the use of ovulation suppression agents for subfertile women with endometriosis seeking conception.
Further research may be needed to clarify the role of specific agents or patient subgroups.