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Related Experiment Video

Updated: Jul 13, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

WITHDRAWN: Folate supplementation in pregnancy.

¹Ipswich Hospital, Ipswich, Queensland, Australia, 4305. kassam_mahomed@health.qld.gov.au

The Cochrane Database of Systematic Reviews

|July 20, 2007

Summary

Folate supplementation during pregnancy improves folate status and hemoglobin levels, potentially reducing anemia. However, evidence for other clinical outcomes in mother and baby remains insufficient.

Area of Science:

Obstetrics and Gynecology
Nutritional Science
Hematology

Background:

Folate deficiency is a known cause of anemia in pregnant individuals.
Maintaining adequate folate levels is crucial for a healthy pregnancy.

Purpose of the Study:

To evaluate the impact of folate supplementation during pregnancy on hematological and biochemical markers.
To assess the effects on pregnancy outcomes, excluding fetal malformations related to periconceptual supplementation.

Main Methods:

Systematic review of controlled trials comparing folate supplementation to placebo or no treatment in pregnant women.
Inclusion of trials involving women with normal hemoglobin levels.
Assessment of trial quality and data extraction.

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Main Results:

Folate supplementation significantly increased serum and red blood cell folate levels.
It was associated with a reduced proportion of women with low hemoglobin levels and megaloblastic erythropoiesis.
A potential reduction in low birthweight was observed, but other clinical outcomes were not significantly affected.

Conclusions:

Folate supplementation during pregnancy positively impacts folate status and hemoglobin levels.
Further research is needed to determine the effects of folate supplementation on clinical outcomes for both mother and infant.