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Related Experiment Video

Updated: Jul 13, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

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WITHDRAWN: Dehydroepiandrosterone (DHEA) supplementation for cognitive function.

F A Huppert¹, J K Van Niekerk

¹University of Cambridge, Department of Psychiatry, Box 189 Addenbrooke's Hospital, Cambridge, UK, CB2 2QO. fah2@cus.cam.ac.uk

The Cochrane Database of Systematic Reviews

|July 20, 2007

Summary

Dehydroepiandrosterone (DHEA) supplementation shows no current cognitive benefits in older adults or those with dementia. Further long-term, high-quality trials are needed to explore potential neuroprotective effects.

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Area of Science:

Neuroscience
Endocrinology
Gerontology

Background:

Theoretical rationale suggests Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) may benefit cognitive function in aging and dementia.
Widespread public use of DHEA supplements necessitates a scientific evaluation of their efficacy and safety.
Current DHEA dosages vary, particularly between sexes, highlighting the need for evidence-based recommendations.

Purpose of the Study:

To determine if DHEA or DHEAS administration enhances cognitive function in healthy older adults.
To assess if DHEA or DHEAS slows cognitive decline in individuals with dementia.
To provide a scientific basis for DHEA/S dosage, administration, and side effect profiles.

Main Methods:

Systematic review of randomized controlled trials (RCTs) investigating DHEA/S effects on cognition in older adults.
Inclusion criteria encompassed all relevant RCTs of DHEA/S.
Independent data extraction by two reviewers; no meta-analysis due to data limitations.

Main Results:

Four studies were included; none focused on dementia.
One study showed improved visual memory recall in women after 2 weeks of DHEA, but no effects in men or on verbal memory.
DHEA did not consistently improve cognition, and one study indicated potential impairment in visual memory under stress; side effects were minimal.

Conclusions:

Current data do not support DHEA treatment for improving memory or cognitive function in older adults.
High-quality, long-term trials (over one year) with sufficient participants are required to detect potential neuroprotective effects.
Results from ongoing trials in Alzheimer's Disease, post-menopausal women, and older men will be incorporated.