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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: Jul 13, 2026

The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
08:27

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Published on: July 25, 2011

Mannitol for acute stroke.

D Bereczki1, I Fekete, G F Prado

  • 1University of Debrecen, Department of Neurology, Nagyerdei krt. 98, Debrecen, Hungary, H-4012. bereczki@dote.hu

The Cochrane Database of Systematic Reviews
|July 20, 2007
PubMed
Summary

Mannitol, an osmotic agent, showed no proven benefits or harms in acute stroke patients. More research is needed to determine its effectiveness in treating stroke, as current evidence is insufficient.

Area of Science:

  • Neurology
  • Clinical Trials
  • Pharmacology

Background:

  • Mannitol is an osmotic agent and free radical scavenger with potential to reduce edema and tissue damage in stroke.
  • Acute stroke, encompassing ischemic stroke and intracerebral hemorrhage (ICH), remains a leading cause of death and disability.

Purpose of the Study:

  • To evaluate the efficacy of mannitol in reducing short- and long-term case fatality and dependency following acute ischemic stroke or ICH.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) comparing mannitol with placebo or open control.
  • Searches conducted across multiple databases including Cochrane Stroke Group Trials Register, MEDLINE, and others up to January 2007.
  • Data extraction and analysis performed independently by two review authors.

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Main Results:

  • Three small trials with 226 participants were included; one for ischemic stroke and two for CT-verified ICH.
  • Primary outcome data (death and dependency) were unavailable in any trial.
  • No significant differences in case fatality, death, disability, or clinical improvement were observed between mannitol and control groups in ICH trials. Case fatality was not reported for ischemic stroke.

Conclusions:

  • Current evidence is insufficient to support the routine use of mannitol in acute stroke patients.
  • Further randomized controlled trials are necessary to definitively establish the benefits or harms of mannitol in acute stroke management.