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Related Experiment Video

Updated: Jul 13, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

Pentoxifylline for treating venous leg ulcers.

A Jull¹, B Arroll, V Parag

¹University of Auckland, Clinical Trials Research Unit, Private Bag 92019, Auckland, New Zealand. a.jull@ctru.auckland.ac.nz

The Cochrane Database of Systematic Reviews

|July 20, 2007

Summary

Pentoxifylline improves venous leg ulcer healing, especially when used with compression therapy. This drug may also be effective without compression, though gastrointestinal side effects are common.

Related Experiment Videos

Last Updated: Jul 13, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

Area of Science:

Vascular Medicine
Dermatology
Pharmacology

Background:

Compression bandaging enhances venous leg ulcer healing but is not suitable for all patients.
Some venous leg ulcers remain unhealed despite compression therapy.
Pentoxifylline, a hemorheologic agent, has been explored for treating venous leg ulcers.

Purpose of the Study:

To evaluate the efficacy of pentoxifylline in treating venous leg ulcers.
To compare pentoxifylline with placebo or other therapies.
To assess pentoxifylline's effectiveness with and without concurrent compression therapy.

Main Methods:

Systematic review and meta-analysis of randomized controlled trials.
Searched multiple databases including Cochrane Wounds Group Register, CENTRAL, MEDLINE, EMBASE, and Cinahl.
Included 12 trials with 864 participants comparing pentoxifylline to placebo or other treatments, with or without compression.

Main Results:

Pentoxifylline demonstrated significantly higher complete or improved ulcer healing rates compared to placebo (RR 1.70).
The combination of pentoxifylline and compression therapy was more effective than placebo with compression (RR 1.56).
Pentoxifylline showed effectiveness even in the absence of compression (RR 2.25), but was associated with increased adverse effects, primarily gastrointestinal.

Conclusions:

Pentoxifylline serves as an effective adjunct to compression bandaging for venous ulcer treatment.
Pentoxifylline may offer therapeutic benefits for venous leg ulcers even when compression is not used.
Gastrointestinal disturbances were the most frequently reported adverse effects associated with pentoxifylline therapy.