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Related Experiment Videos

Epidemiology of primary hyperparathyroidism.

L J Melton1

  • 1Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|October 1, 1991
PubMed
Summary

Primary hyperparathyroidism (HPT) affects more women and older adults, with significant hospitalization and treatment costs. Further research is needed before population-wide screening for HPT is considered.

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Area of Science:

  • Endocrinology
  • Public Health
  • Epidemiology

Background:

  • The population impact of primary hyperparathyroidism (HPT) remains poorly documented, especially for asymptomatic cases.
  • Limited data exists on HPT-related mortality, hospitalization rates, and treatment interventions like parathyroidectomy.
  • Existing prevalence and incidence data suggest HPT is more common in women and increases with age.

Purpose of the Study:

  • To document the population impact of primary hyperparathyroidism (HPT).
  • To review available data on HPT incidence, prevalence, and treatment rates.
  • To highlight the need for further research on HPT management and cost-effectiveness.

Main Methods:

  • Analysis of national mortality and hospitalization data from 1986.

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  • Inclusion of population-based incidence and prevalence studies (Rochester, MN; Sweden).
  • Review of parathyroidectomy rates and discussion of cost and disability implications.

    • Main Results:

    • In 1986, HPT death rate was 0.24 per million; hospitalization incidence was 6.6 per 100,000.
    • Approximately 10,000 parathyroidectomies were performed in the US in 1986.
    • Estimated HPT incidence was 42.1 per 100,000; prevalence was 4.3 per 1000 in Sweden.
    • HPT is more prevalent in women and older individuals.

    Conclusions:

    • Primary hyperparathyroidism (HPT) is more common than previously thought, particularly in women and the elderly.
    • Significant costs and lack of data on disability and treatment effectiveness hinder management strategies.
    • Aggressive population screening for HPT is premature until patient management and cost issues are resolved.