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Related Experiment Videos

Longitudinal changes in forearm bone mineral content in primary hyperparathyroidism.

J Warner1, P Clifton-Bligh, S Posen

  • 1Department of Endocrinology, Royal North Shore Hospital, St. Leonards, New South Wales, Australia.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|October 1, 1991
PubMed
Summary

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Successful parathyroidectomy improved forearm bone mineral content in primary hyperparathyroidism patients. Bone mineral density increased post-surgery, unlike in untreated hyperparathyroidism or control groups.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Mineral Homeostasis

Background:

  • Primary hyperparathyroidism is a common endocrine disorder.
  • It is associated with bone loss and increased fracture risk.
  • Parathyroidectomy is the definitive treatment for symptomatic primary hyperparathyroidism.

Purpose of the Study:

  • To evaluate the effect of parathyroidectomy on forearm bone mineral content in patients with primary hyperparathyroidism.
  • To compare bone mineral changes in parathyroidectomized patients with those in patients with ongoing hyperparathyroidism and healthy controls.

Main Methods:

  • Forearm bone mineral content (BMC) was measured in 28 patients before and 1 year after parathyroidectomy.
  • A separate study measured BMC in 10 women with hyperparathyroidism before and for 2 years after parathyroidectomy.

Related Experiment Videos

  • These were compared to 12 women with ongoing hyperparathyroidism and 12 eucalcemic controls over 2 years.

    • Main Results:

    • Forearm BMC increased significantly (P < 0.05) 1 year after parathyroidectomy in the first group.
    • The parathyroidectomized group gained bone over 2 years, while the ongoing hyperparathyroid and control groups lost bone.
    • The difference in bone gain between parathyroidectomized and ongoing hyperparathyroid groups was significant (P < 0.05) after 2 years.

    Conclusions:

    • Parathyroidectomy leads to significant improvement in forearm bone mineral content in primary hyperparathyroidism.
    • Surgical treatment of hyperparathyroidism can reverse bone loss associated with the condition.
    • Initial bone mineral content may influence bone loss in older women, irrespective of hyperparathyroidism status.