Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dataset on India's imports of <i>Penaeus vannamei</i> brooders from the United States.

Data in brief·2025
Same author

LMCT-Driven Iron Photocatalysis: Mechanistic Insights and Synthetic Applications.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same author

Extensive Studies on the Synthesis and Characterization of π-Arene Chromium Complexes and Their Performance in S<sub>N</sub>Ar and Suzuki-Miyaura Cross-Coupling Reactions.

Chemistry, an Asian journal·2025
Same author

Selective C-H Borylation of Polyaromatic Compounds Enabled by Metal-Arene π-Complexation.

Journal of the American Chemical Society·2025
Same author

Estuarine mangrove niches select cultivable heterotrophic diazotrophs with diverse metabolic potentials-a prospective cross-dialog for functional diazotrophy.

Frontiers in microbiology·2024
Same author

Ecological restoration at pilot-scale employing site-specific rationales for small-patch degraded mangroves in Indian Sundarbans.

Scientific reports·2024

Related Experiment Video

Updated: Jul 13, 2026

Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions
09:11

Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions

Published on: October 2, 2018

Does caffeine reverse the EAC cell-induced immune suppression?

Anup Mandal1, Mrinal K Poddar

  • 1Department of Biochemistry, University of Calcutta, 35 B. C. Road, Kolkata - 700 019, India.

The Journal of Pharmacy and Pharmacology
|July 20, 2007
PubMed
Summary

Long-term caffeine intake may counteract immune suppression caused by Ehrlich ascites carcinoma (EAC) cells. Caffeine treatment helped restore immune parameters and reduce the negative effects of EAC cells in mice.

More Related Videos

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Assaying &beta;-amyloid Toxicity using a Transgenic C. elegans Model
13:59

Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

Published on: October 9, 2010

Related Experiment Videos

Last Updated: Jul 13, 2026

Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions
09:11

Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions

Published on: October 2, 2018

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Assaying &beta;-amyloid Toxicity using a Transgenic C. elegans Model
13:59

Assaying β-amyloid Toxicity using a Transgenic C. elegans Model

Published on: October 9, 2010

Area of Science:

  • Immunology
  • Pharmacology
  • Oncology

Background:

  • Ehrlich ascites carcinoma (EAC) is a type of cancer that can induce immune suppression.
  • Caffeine is a widely consumed stimulant with potential immunomodulatory effects.
  • Understanding caffeine's impact on cancer-associated immune dysfunction is crucial.

Purpose of the Study:

  • To investigate the effect of long-term caffeine consumption on immune responses during Ehrlich ascites carcinoma (EAC) development in mice.
  • To assess caffeine's ability to mitigate EAC-induced immune suppression.

Main Methods:

  • Adult female mice were treated with caffeine daily for 22-27 days.
  • Mice were inoculated with EAC cells or co-treated with caffeine and EAC cells.
  • Immune response parameters including lymphocyte viability, proliferation, cytotoxicity, DNA fragmentation, and corticosterone levels were measured.

Main Results:

  • EAC cell development led to significant immune suppression, characterized by reduced lymphocyte function and increased corticosterone.
  • Long-term caffeine treatment alone did not significantly alter immune parameters.
  • Concurrent caffeine treatment during EAC development partially restored immune function and reduced corticosterone levels.

Conclusions:

  • Long-term caffeine intake may inhibit or reverse EAC cell-induced immune suppression.
  • Caffeine demonstrates potential as an adjuvant therapy to manage cancer-related immune dysfunction.
  • Further research is warranted to explore caffeine's therapeutic potential in oncology.