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Published on: May 23, 2025

[Cardiac abnormalities in antiphospholipid syndrome]

Xiao-mei Meng1, Yan Zhao, Li-gang Fang

  • 1Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

Zhonghua Nei Ke Za Zhi
|July 20, 2007
PubMed

Insights

Antiphospholipid syndrome (APS) frequently causes cardiac issues, including valve abnormalities and thrombosis. Anticoagulation therapy effectively prevented further thrombotic events in patients with cardiac involvement.

Area of Science:

  • Rheumatology
  • Cardiology
  • Hematology

Context:

  • Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent thrombosis and pregnancy morbidity.
  • Cardiac involvement is a significant but often under-recognized complication of APS.

Purpose:

  • To investigate the clinical manifestations, treatment, and prognosis of antiphospholipid syndrome (APS).
  • To analyze the relationship between cardiac abnormalities and thrombotic events in APS patients.

Summary:

  • A retrospective analysis of 72 APS patients revealed vascular thrombosis in 59.7% and cardiac abnormalities in 66.6%.
  • Mitral valve involvement was common, and cardiac abnormalities were significantly associated with thrombosis and prolonged activated partial thromboplastin time (APTT).
  • Anticoagulation therapy was effective in preventing recurrent thrombosis in APS patients with cardiac involvement.

Impact:

  • Highlights the high prevalence of cardiac manifestations in APS.
  • Underscores the link between hypercoagulability, cardiac involvement, and thrombotic events in APS.
  • Provides evidence for the efficacy of anticoagulation in managing APS-related cardiac complications.
Abstract

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