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Published on: January 28, 2020
[The relationship between high-sensitivity C-reactive protein and peripheral artery disease]
1Department of Preventive Medicine, Medical College, Tongji University, Shanghai 200092, China.
Zhonghua Nei Ke Za Zhi
|July 20, 2007
Summary
High-sensitivity C-reactive protein (hs-CRP) is linked to peripheral arterial disease (PAD). Elevated hs-CRP levels independently predict PAD risk in Chinese adults over 40.
Area of Science:
- Biomedical Research
- Cardiovascular Health
- Inflammation Markers
Context:
- Peripheral arterial disease (PAD) is a significant manifestation of atherosclerosis.
- High-sensitivity C-reactive protein (hs-CRP) is a marker of systemic inflammation.
- The relationship between hs-CRP and PAD requires further elucidation, particularly in diverse populations.
Purpose:
- To examine the association between hs-CRP levels and the presence of PAD.
- To determine if hs-CRP is an independent risk factor for PAD in Chinese adults aged 40 and above.
Summary:
- A study of 643 adults (≥40 years) measured hs-CRP and ankle-brachial index (ABI).
- 10% of subjects had PAD (ABI < 0.9). Higher prevalence of smoking, hypertension, diabetes, low HDL, and cardiovascular disease history was observed in PAD patients.
- Logistic regression revealed that moderate and high hs-CRP groups had a two-fold increased odds ratio for PAD compared to the low hs-CRP group. High hs-CRP remained a significant predictor after adjusting for cardiovascular risk factors (P=0.007).
Impact:
- This research highlights hs-CRP as a valuable inflammatory biomarker for identifying individuals at risk of PAD.
- Findings suggest that hs-CRP measurement could aid in risk stratification for PAD in clinical practice.
- The study underscores the importance of managing inflammation in preventing PAD progression.
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