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Aphthous ulcerations associated with trisomy 8-positive myelodysplastic syndrome
Lauren A Fine1, Laura D Hoffman, Mark D Hoffman
1Department of Dermatology, Rush University, Chicago, Illinois, IL 60612, USA.
Abstract:
The association of Behçet's disease with myelodysplastic syndromes has been established in the hematologic, gastrointestinal, and medical genetics literature; trisomy 8 is a feature present in 70% of these reports. Because trisomy 8 is ordinarily present in only 14% of patients with myelodysplastic syndrome, this is a significant overrepresentation. We describe a patient with recurrent aphthous stomatitis who was subsequently diagnosed with trisomy 8-positive myelodysplastic syndrome after an unexplained macrocytosis was further investigated.
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