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Related Experiment Videos

Pulmonary embolism - temporal changes.

Ivo Steiner1

  • 1Fingerland Department of Pathology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, 500 05 Hradec Kralove, Czech Republic. steiner@lfhk.cuni.cz

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|July 20, 2007
PubMed
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Autopsy studies reveal a declining incidence of pulmonary thromboembolism (PE) from 19.2% in 1960 to 10.0% in 2005. Despite diagnostic advancements, PE remains a challenging condition to accurately diagnose clinically.

Area of Science:

  • Pathology
  • Clinical Diagnostics
  • Epidemiology

Background:

  • Clinical diagnosis of pulmonary thromboembolism (PE) is often inaccurate, leading to misdiagnosis.
  • Autopsy remains the gold standard for PE diagnosis, but recent data are scarce and debated.

Purpose of the Study:

  • To retrospectively analyze autopsy data on PE incidence from 1960 to 2005.
  • To identify trends in PE prevalence, patient demographics, and seasonal variations.

Main Methods:

  • Retrospective review of autopsy records from 1960 to 2005.
  • Analysis of 3877 adult autopsies across six reference years.
  • Examination of PE incidence, patient age, sex, and time of death.

Main Results:

Related Experiment Videos

  • Overall PE autopsy incidence declined from 19.2% in 1960 to 10.0% in 2005.
  • PE incidence was higher in women (19.4%) than men (13.7%).
  • Average age of PE patients increased from 63.7 to 69.6 years; incidence peaked in November.

    • Conclusions:

    • Autopsy-confirmed PE incidence has steadily decreased over 45 years.
    • Underlying causes of PE have remained consistent.
    • Pulmonary thromboembolism remains a difficult condition to diagnose accurately despite clinical progress.