Related Experiment Video
Updated: Jul 13, 2026

07:44
Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
Published on: May 12, 2023
Vaccination and risk groups: how can we really protect the weakest?
1Department of Public Health, University of Florence, Florence, Italy. paolo.vonanni@unifi.it
Human Vaccines
|July 20, 2007
Summary
Targeted vaccination strategies often fail to protect at-risk populations. Routine immunization programs, however, effectively protect vulnerable individuals by establishing community immunity, benefiting even the unvaccinated.
Area of Science:
- Public Health
- Epidemiology
- Immunization Practices
Background:
- Individuals with specific clinical conditions, age, occupation, or living situations are at higher risk for preventable infectious diseases.
- Previous attempts to identify and vaccinate these high-risk groups have often been unsuccessful in achieving adequate coverage.
Purpose of the Study:
- To evaluate the effectiveness of targeted versus routine vaccination strategies in protecting vulnerable populations.
- To highlight the limitations of identifying and vaccinating specific at-risk groups.
Main Methods:
- Analysis of historical and recent vaccination campaign data.
- Comparative assessment of targeted vaccination approaches versus broad, cohort-based routine immunization.
Main Results:
- Targeted vaccination strategies frequently fail to reach a significant proportion of at-risk individuals.
- Routine vaccination strategies, when well-implemented, demonstrate success in protecting vulnerable populations through community immunity.
- Community protection positively impacts even unvaccinated individuals within the community.
Conclusions:
- Routine immunization is a more effective and ethical approach to protecting vulnerable populations than targeted strategies.
- Delaying universal immunization until high-risk groups are covered is counterproductive and potentially harmful to those it aims to protect.
Related Concept Videos
Vaccinations
Overview
Vaccines
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Smallpox
Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Transmission-based Precautions II: Airborne and Protective Environment
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...

