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Updated: Jul 13, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Ibuprofen, the propionics and NSAIDs: personal reflections over four decades
150 Salcombe Drive, Arnold, Nottingham, NG5 8JF, England, UK.
Researchers began rheumatoid arthritis (RA) studies in 1952 at Boots Co. in Nottingham, UK. Early work faced challenges due to suboptimal laboratory conditions in a repurposed Victorian house.
Area of Science:
- Pharmacology
- Rheumatology
Background:
- The Boots Co. Pharmacological Division relocated to a Victorian house during WWII for safety.
- Research activities were compromised by the suboptimal conditions in the new facility.
Purpose of the Study:
- To initiate research into rheumatoid arthritis (RA).
Main Methods:
- Conducting pharmacological research within a challenging laboratory environment.
Main Results:
- Early research efforts in RA were undertaken despite environmental constraints.
Conclusions:
- The initial phase of RA research commenced under adverse conditions, highlighting the dedication of the research team.
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