Related Experiment Video
Updated: Jul 13, 2026

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
Published on: June 11, 2015
A mathematical approach to predicting biological values from ruminal pH measurements
O AlZahal1, E Kebreab, J France
1Centre for Nutrition Modelling, Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1.
This study introduces a novel logistic model to analyze ruminal pH data, offering a better way to understand how diet affects rumen health. The model quantizes pH changes, aiding comparisons across studies and dietary treatments.
Area of Science:
- Animal Science
- Ruminant Nutrition
- Dairy Cattle Research
Background:
- Continuous ruminal pH monitoring is crucial for understanding digestive health in ruminants.
- Traditional methods summarize pH data using mean, min, max, time, and area below thresholds.
- A more sophisticated analysis is needed to capture the nuances of ruminal pH dynamics.
Purpose of the Study:
- To develop and validate a novel mathematical approach for analyzing continuous ruminal pH data.
- To compare the fit of different sigmoidal growth functions for summarizing ruminal pH.
- To derive biologically relevant parameters from the best-fit model to quantify dietary effects on ruminal pH.
Main Methods:
- A meta-analysis of 613 records from 6 published studies was conducted.
- Ruminal pH data were categorized by non-fiber carbohydrate (NFC) content: low, moderate, and high.
- Sigmoidal curves (spline, Morgan, Richards, logistic) were fitted to time-below-pH data using nonlinear modeling.
Main Results:
- The logistic and Richards equations provided a better fit to the ruminal pH data than spline lines and the Morgan model.
- The logistic equation, with fewer parameters, consistently offered superior prediction accuracy.
- Model-derived values, such as inflection points, effectively quantified the impact of NFC on ruminal pH depression.
Conclusions:
- The logistic equation is the most suitable model for describing ruminal pH curves.
- Model-derived biological values offer a robust method for summarizing and comparing ruminal pH data across different studies and diets.
- This approach enhances the quantification of dietary effects on ruminal pH, particularly in relation to NFC levels.
Related Concept Videos
Measurement of Bioavailability: Pharmacodynamic Methods
Dosage Regimens: Partial Pharmacokinetic Parameters
Measurement of Bioavailability: Pharmacokinetic Methods
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Physiological Pharmacokinetic Models: Assumption with Protein Binding

