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In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses
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[Selection and use of anti-infective agents for intra-abdominal infections]

Júlio Cezar Uili Coelho1, Giorgio Alfredo Pedroso Baretta, Luciano Okawa

  • 1Serviço de Cirurgia do Aparelho Digestivo, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR. juliocoelho@bbs2.sul.com.br

Arquivos De Gastroenterologia
|July 20, 2007
PubMed
Abstract

Insights

Appropriate antibiotic selection is crucial for treating intra-abdominal infections, considering common pathogens like E. coli. Regimens differ for community- versus hospital-acquired infections due to varying microbial resistance patterns.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Context:

  • Intra-abdominal infections (IAIs) are prevalent, leading to significant morbidity and mortality.
  • Common causative agents include Escherichia coli and Bacteroides fragilis from gastrointestinal flora.

Purpose:

  • To review the principles and practices for selecting and utilizing antibiotic therapy in the management of IAIs.
  • To guide clinicians in optimizing antimicrobial strategies for IAIs.

Summary:

  • Antibiotic therapy is initiated upon suspicion of IAIs, targeting prevalent microorganisms.
  • Selection criteria include efficacy, cost, safety, and dosage regimens.
  • Distinction in antibiotic selection is made between community-acquired and hospital-acquired IAIs due to differences in microbial resistance.

Impact:

  • Optimizing antibiotic use is essential for effective infection control and reducing treatment failures.
  • Tailored antibiotic regimens improve patient outcomes and minimize the development of antimicrobial resistance.

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