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Retinal function and PKC alpha expression after focal laser photocoagulation.

Karin Gjörloff Wallentén1, Malin Malmsjö, Sten Andréasson

  • 1Department of Ophthalmology, Lund University Hospital, 22185 Lund, Sweden.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|July 20, 2007
PubMed
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Focal laser photocoagulation alters retinal function and protein kinase C (PKC) alpha expression in rabbits. This laser treatment causes widespread changes in both rod and cone function, impacting PKC alpha levels in retinal cells.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Cell Biology

Background:

  • Focal laser photocoagulation is a common ophthalmic procedure.
  • Understanding its effects on retinal function and molecular changes is crucial.
  • Protein Kinase C (PKC) alpha plays a role in retinal signaling.

Purpose of the Study:

  • To investigate the impact of focal laser photocoagulation on rabbit retinal function.
  • To analyze changes in Protein Kinase C (PKC) alpha expression post-treatment.
  • To correlate electrophysiological findings with PKC alpha alterations.

Main Methods:

  • Rabbits underwent focal laser photocoagulation in the central retina.
  • Full-field and multifocal electroretinography (ERG and mfERG) were used to assess retinal function.

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  • Immunohistochemistry and real-time PCR quantified PKC alpha and glial fibrillary acidic protein (GFAP) expression.

    • Main Results:

    • Full-field ERG showed increased b-wave amplitudes for rod and cone responses post-laser.
    • Multifocal ERG revealed increased implicit times in the central retina.
    • PKC alpha expression and mRNA levels progressively decreased in rod bipolar cells, with GFAP upregulation observed.

    Conclusions:

    • Focal laser treatment induces significant, widespread alterations in retinal function.
    • A progressive downregulation of PKC alpha in rod bipolar cells accompanies these functional changes.
    • Laser photocoagulation interferes with PKC alpha-mediated inhibitory regulation of retinal signal transmission.