Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct regions...
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prospective comparison of diagnostic accuracy of ultrasound, PET/CT and DW-MRI for preoperative assessment of pelvic lymph nodes in cervical cancer patients: results of the CANNES trial.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2026
Same author

Global RNA expression analysis of patient samples identified potential diagnostic biomarkers specific for peritoneal, ovarian and deep endometriosis.

Scientific reports·2026
Same author

Comparison of ultrasound with computed tomography and whole-body diffusion-weighted MRI in prediction of surgical outcome using ESMO-ESGO criteria in patients with tubo-ovarian carcinoma: prospective ISAAC study.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

The role of HPV testing in the follow-up of patients in different clinical scenarios after diagnosis of cervical preinvasive lesions and carcinomas.

Expert review of anticancer therapy·2025
Same author

Practical recommendations for the use of PARP inhibitors in the treatment of ovarian cancer.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2025
Same author

Dostarlimab and niraparib in primary advanced ovarian cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2025

Related Experiment Video

Updated: Jul 13, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

[Late (non-classic) adrenal hyperplasia].

M Fanta1, D Cibula, J Vrbíková

  • 1Gynekologicko-porodnická klinika VFN a 1. LF UK, Praha. mfanta@vfn.cz

Ceska Gynekologie
|July 21, 2007
PubMed
Summary

Non-classic adrenal hyperplasia (NCAH) due to 21-hydroxylase deficiency is rare, even in hyperandrogenic women. Measuring 17OH-progesterone is key for diagnosing NCAH, which mimics PCOS symptoms.

More Related Videos

Establishment of Zone-Enriched Primary Cultures from the Mouse Adrenal Cortex
07:43

Establishment of Zone-Enriched Primary Cultures from the Mouse Adrenal Cortex

Published on: May 8, 2026

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

Related Experiment Videos

Last Updated: Jul 13, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Establishment of Zone-Enriched Primary Cultures from the Mouse Adrenal Cortex
07:43

Establishment of Zone-Enriched Primary Cultures from the Mouse Adrenal Cortex

Published on: May 8, 2026

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

Area of Science:

  • Endocrinology
  • Genetics
  • Reproductive Medicine

Background:

  • 21-hydroxylase deficiency is a common autosomal recessive disorder.
  • Non-classic adrenal hyperplasia (NCAH) presents with hyperandrogenism.
  • NCAH prevalence is low in the general population and hyperandrogenic women.

Purpose of the Study:

  • To review data on adrenal hyperandrogenism caused by 21-hydroxylase deficiency (NCAH).
  • To highlight diagnostic and management strategies for NCAH.

Main Methods:

  • Review article based on scientific literature compilation.
  • Analysis of diagnostic criteria and treatment modalities for NCAH.

Main Results:

  • NCAH is rare, with non-specific symptoms often resembling Polycystic Ovary Syndrome (PCOS).
  • 17-hydroxyprogesterone measurement is crucial for NCAH diagnosis.
  • Corticosteroid and anti-androgen therapies are used, with combined oral contraceptives as a primary treatment.

Conclusions:

  • Early diagnosis of NCAH through 17OH-progesterone testing is recommended for hyperandrogenic patients.
  • Treatment focuses on symptom improvement, with no data on long-term metabolic risks.