Related Experiment Video
Updated: Jul 13, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
[Preparation and quality evaluation of quercetin self-emulsifyied drug delivery systems]
Ying Hu1, Hai-Liang Chen, Wen-Quan Liang
1Department of Pharmacy, Zhejiang Pharmaceutical College, Ningbo 315100, China.
Objective:
To prepare the quercetin self-emulsified formulation and evaluate its quality.
Method:
The quercetin self-emulsified formulation was optimized based on the quercetin solubility in different oils, and the self-microemulsified efficiency of various combinations of emulsifier and co-emulsifier evaluated using the pseudo-ternary phase diagram. The microemulsion of morphology, size and zeta potential were examined. The quercetin of solubility in self-emulsified system was tested and the formulation stability was investigated by accelerated experiment.
Result:
The blank self-emulsified system was composed of ethyl oleate/Cremophor EUL/butanol with weight ratio of 10: 54: 36. After being dilutied with water, the morphology of microemulsion was homogeneous small spherical drops observed under the electro-microscopy. The particle size and the zeta potential were 16.3 +/- 4.6 nm and 2.1 +/- 0.8 mV, respectively. The solubility of quercetin in self-emulsifing system was (62.42 +/- 0.11) mg x mL(-1), increased 2 229 folds compared with that of in water. The quality of quercetin self-emulsified formulation was stable during the 3 months storage at 40 degrees C.
Conclusion:
The solubility of quercetin is significantly increased in self-emulsified system and the formulation is stable and easy to prepare.
Related Concept Videos
Oral Drug Delivery Systems: Introduction
Oral Drug Delivery Systems: Delayed-Release Systems
Modified-Release Drug Delivery Systems: Overview
Modified-Release Drug Delivery Systems: Site-Targeted
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Factors Influencing Drug Absorption: Pharmaceutical Parameters
