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Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
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All that glitters is not gold: all that FLICA binds is not caspase. A caution in data interpretation--and new

Zbigniew Darzynkiewicz1, Piotr Pozarowski

  • 1Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA. darzynk@nymc.edu

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
|July 21, 2007
PubMed
Abstract

No abstract available in PubMed .

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Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.

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