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Typical type-C virus in human leukemia.

W T Hall, G Schidlovsky

Journal of the National Cancer Institute

|March 1, 1976

Summary

This summary is machine-generated.

The newly discovered HL-23 virus from leukemia patients resembles mammalian type-C viruses. This finding distinguishes it from previously identified human virus particles, suggesting a potential new viral classification.

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Area of Science:

Virology
Oncology
Electron Microscopy

Background:

The human leukemia virus HL-23 was recently isolated from a myelogenous leukemia patient.
Virus-like particles have been observed in various human tissues.
Mammalian type-C viruses are a known class of retroviruses.

Purpose of the Study:

To compare the morphology of the HL-23 virus with other known virus particles.
To determine the classification of the HL-23 virus based on its ultrastructural characteristics.

Main Methods:

Electron microscopy was used for high-resolution imaging of viral particles.
Comparative analysis was performed between HL-23, human tissue particles, and mammalian type-C viruses.

Main Results:

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The HL-23 virus exhibited a close resemblance to typical type-C virus particles found in murine, feline, and nonhuman primate species.
Significant morphological differences were noted between HL-23 and previously reported human tissue particles, including atypical human placental particles.

Conclusions:

The HL-23 virus shares morphological characteristics with mammalian type-C viruses.
HL-23 represents a distinct viral entity compared to other human-associated particles identified to date.