Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Classification of Leukocytes

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...

Disorders of Leukocytes

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...

Disorders of Erythrocytes

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...

Accessory Structures of the Skin: Nails

Accessory Structures of the Skin: Nails

Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

Drugs that Destabilize Microtubules

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nonlinear-optical energy regulation by nonlinear refraction and absorption in silicon.

Optics letters·2009

Same author

Electrically tunable Bragg gratings in single-mode polymer optical fiber.

Optics letters·2007

Same author

Heparin-induced thrombocytopenia: recent experience in a large teaching hospital.

Internal medicine journal·2006

Same author

Pneumonitis associated with leflunomide: a profile of New Zealand and Australian reports.

Internal medicine journal·2006

Same author

Concordance between clopidogrel use and prescribing guidelines.

Internal medicine journal·2004

Same author

Evaluation of cyclooxygenase 2 inhibitor use in patients admitted to a large teaching hospital.

Internal medicine journal·2003

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

Measuring Granulocyte and Monocyte Phagocytosis and Oxidative Burst Activity in Human Blood

Measuring Granulocyte and Monocyte Phagocytosis and Oxidative Burst Activity in Human Blood

Published on: September 12, 2016

Toenails and agranulocytosis.

P I Pillans¹, I W Boyd

¹Department of Clinical Pharmacology, Princess Alexandra Hospital, Brisbane, Queensland, Australia. peter_pillans@health.qld.gov.au

Internal Medicine Journal

|July 21, 2007

Summary

This summary is machine-generated.

Terbinafine can cause severe neutropenia (low white blood cell count), a rare but serious side effect. Early recognition and drug withdrawal are crucial for patient recovery.

More Related Videos

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Published on: May 12, 2023

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

Related Experiment Videos

Last Updated: Jul 13, 2026

Measuring Granulocyte and Monocyte Phagocytosis and Oxidative Burst Activity in Human Blood

Measuring Granulocyte and Monocyte Phagocytosis and Oxidative Burst Activity in Human Blood

Published on: September 12, 2016

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay

Published on: May 12, 2023

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

Area of Science:

Dermatology
Hematology
Pharmacology

Background:

Terbinafine is a widely used antifungal medication for skin and nail infections.
Granulocytopenia, including severe neutropenia and agranulocytosis, is a rare but potentially life-threatening adverse effect.
Understanding the clinical presentation and management of terbinafine-induced neutropenia is essential.

Observation:

A study reviewed 12 Australian cases of granulocytopenia linked to terbinafine use.
Patients were predominantly older women, with a mean age of 64 years.
Neutropenia typically developed within 4-5 weeks of terbinafine initiation and was often severe.

Findings:

Most cases presented with severe neutropenia (neutrophil counts < or = 0.3 x 10(3)/mm3).
Symptoms included fatigue, fever, sore throat, and mouth ulceration.
One patient died from septic shock, while others required hospitalization, antibiotics, or granulocyte colony-stimulating factor.

Implications:

Terbinafine use can be associated with severe, rarely fatal, granulocytopenia.
Prompt discontinuation of terbinafine and management of neutropenia are critical.
Patients must be educated about the warning signs of this adverse reaction.