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Related Experiment Video

Updated: Jul 13, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Primary cutaneous adenomyoepithelioma.

Loren E Clarke¹, John T Seykora

¹Division of Dermatopathology, Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

Journal of Cutaneous Pathology

|July 21, 2007

Summary

A rare skin tumor, primary cutaneous adenomyoepithelioma, was identified in an 83-year-old woman. This adenomyoepithelioma, typically found in the breast, may present as a borderline malignant neoplasm.

Area of Science:

Dermatopathology
Oncology

Background:

Primary cutaneous adenomyoepithelioma is an exceptionally rare neoplasm.
This tumor is part of a broader spectrum of epithelial-myoepithelial tumors.

Observation:

An 83-year-old woman presented with a large, long-standing subcutaneous thigh tumor that had recently enlarged.
Histopathologic examination revealed a multinodular tumor with glandular structures and both epithelial and myoepithelial cell layers.

Findings:

The lesion's features were consistent with primary cutaneous adenomyoepithelioma, a rare variant of adenomyoepithelioma typically found in the breast.
Histologically, it shares features with common cutaneous lesions like spiradenomas and chondroid syringomas.
The tumor can mimic malignant conditions such as metastatic adenocarcinoma.

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Last Updated: Jul 13, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Implications:

Primary cutaneous adenomyoepithelioma, like its breast counterpart, should be considered a neoplasm with borderline malignant potential.
Accurate histopathologic diagnosis is crucial to differentiate it from other cutaneous tumors, including malignant ones.
Further research is needed to fully understand the behavior and management of this rare tumor.