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Malignant transformation of hamster brain cells in vitro by human papovavirus Bk

R Tanaka, H Koprowski, Y Iwasaki

Journal of the National Cancer Institute

|March 1, 1976

Abstract:

Human papovavirus BK caused the malignant transformation in vitro of brain cells prepared from newborn hamsters. The transformed cells produced BK virus T antigen and grew as tumors after sc inoculation ito hamsters that developed antibodies to BK virus T antigen. The histopathology of the tumors revealed an undifferentiated glioma.

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