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Related Experiment Video

Updated: Jul 13, 2026

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
07:50

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model

Published on: September 3, 2020

Cell therapy for acute myocardial infarction.

Rajiv Gulati1, Robert D Simari

  • 1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

The Medical Clinics of North America
|July 21, 2007
PubMed
Summary

Cell therapy using bone marrow and blood stem cells shows promise for acute myocardial infarction (MI). Clinical trials are exploring cell delivery to improve heart function and survival, shifting focus from regeneration to remodeling modulation.

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Published on: September 22, 2014

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Research
  • Stem Cell Biology

Background:

  • Bone marrow and circulating blood contain progenitor cells with potential for myocardial and vascular repair.
  • Pre-clinical studies supported cell therapy for acute myocardial infarction (MI).
  • Clinical trials rapidly followed, investigating autologous cell delivery for left ventricular dysfunction.

Purpose of the Study:

  • To discuss the scientific rationale behind cell therapy strategies for acute myocardial infarction (MI).
  • To provide an overview of completed and ongoing clinical studies in this field.

Main Methods:

  • Review of pre-clinical evidence for progenitor cells in bone marrow and blood.
  • Analysis of clinical trial designs focusing on regional myocardial delivery of autologous cells.
  • Examination of therapeutic goals, including myocardial regeneration and modulation of cardiac remodeling.

Main Results:

  • Clinical trials have investigated cell transplantation for acute and chronic left ventricular dysfunction.
  • Therapeutic focus has evolved from direct myocardial regeneration to influencing scar tissue and promoting tissue survival via paracrine effects.
  • The role of cellular paracrine effects in modulating myocardial remodeling is increasingly emphasized.

Conclusions:

  • Cell therapy for acute MI is supported by pre-clinical findings on progenitor cells.
  • Clinical trials have adapted their strategies, focusing on paracrine mechanisms and remodeling modulation.
  • Further research and clinical evaluation are essential to optimize cell therapy for cardiovascular repair.