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Effect of erythroid differentiation factor on megakaryocytic differentiation of L8057, a murine megakaryoblastic
1Department of Pediatrics, Yokohama City University, School of Medicine, Japan.
Biochemical and Biophysical Research Communications
|December 31, 1991
Abstract:
To assess the potent effect of erythroid differentiation factor (EDF) on megakaryocytopoiesis, effect of EDF on megakaryocytic differentiation of L8057, a murine megakaryoblastic cell line, was examined. EDF potentiated AchE induction of L8057 in a dose dependent manner. The potency of EDF on megakaryocytic differentiation is comparable to that on erythroid differentiation reported previously. The present results suggest that EDF may play a regulatory role in megakaryocytopoiesis as well as in erythropoiesis.