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Related Experiment Videos

The continuing case for the Renshaw cell.

Francisco J Alvarez1, Robert E W Fyffe

  • 1Department of Neuroscience, Cell Biology & Physiology, Boonshoft School of Medicine, Wright State University, 3640 Col. Glenn Hwy, Dayton, OH 45435, USA. francisco.alvarez@wright.edu

The Journal of Physiology
|July 21, 2007
PubMed
Summary
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Renshaw cells, crucial spinal interneurons, develop through genetic and activity-dependent pathways. Understanding these mechanisms clarifies their role in motor control and aids future research.

Area of Science:

  • Neuroscience
  • Spinal Cord Research
  • Motor Control

Background:

  • Renshaw cells are well-characterized spinal interneurons studied for over 50 years.
  • Recent advances allow for in situ identification, enabling detailed studies of their development and connectivity.

Purpose of the Study:

  • To review how mature Renshaw cell properties and synaptic connections develop.
  • To explore the interplay of activity-dependent and genetically specified mechanisms in Renshaw cell ontogeny.

Main Methods:

  • This is a review article, synthesizing existing research.
  • Focuses on integrating findings from studies on Renshaw cell identification, ontogeny, and synaptic organization.

Main Results:

  • Mature Renshaw cell properties and connectivity result from both genetic programming and neural activity.

Related Experiment Videos

  • Novel methods for identifying Renshaw cells in situ have spurred detailed investigations.

    • Conclusions:

    • New insights into Renshaw cell development provide a foundation for experimental manipulation.
    • Clarifying these mechanisms will enhance understanding of their role in modulating motor output.