Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging and endothelial dysfunction.

Francesco Cosentino1, Elena Osto

  • 1Cardiology, 2nd Faculty of Medicine, University "La Sapienza", Rome, Italy. f_cosentino@hotmail.com

Clinical Hemorheology and Microcirculation
|July 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bile acids: New regulators of the cardiometabolic crosstalk.

Pharmacological research·2026
Same author

Impact of ovarian preservation on survival for premenopausal women with early-stage endometrial carcinoma: A systematic review and meta-analysis.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2026
Same author

Prolonged conservative treatment of women with atypical endometrial hyperplasia and early endometrial carcinoma: A systematic review and meta-analysis.

European journal of obstetrics, gynecology, and reproductive biology·2026
Same author

Hypoxia Upregulation of BACH1 Aggravates Pulmonary Hypertension Through TGFBR2/SMAD Pathways.

Circulation·2026
Same author

LTBP4 deficiency inhibits NLRP3 inflammasome activation in cardiomyocytes and attenuates heart failure in male mice.

Nature communications·2026
Same author

Novel biomarkers of early-life cardiovascular health trajectories enabling biological understanding of primary prevention.

European journal of preventive cardiology·2026
Same journal

Blood viscosity values for predicting pathological stroke types (ischemic stroke, hemorrhagic stroke, and stroke mimic) at DR. Cipto Mangunkusumo National Referral Hospital.

Clinical hemorheology and microcirculation·2026
Same journal

Adaptations of blood fluidity markers to progressive resistance training in men.

Clinical hemorheology and microcirculation·2026
Same journal

Changes in whole blood viscosity in patients undergoing percutaneous or surgical intervention for aortic stenosis.

Clinical hemorheology and microcirculation·2026
Same journal

Impairment of cutaneous microcirculation and vasoreactivity in primary hypothyroidism.

Clinical hemorheology and microcirculation·2026
Same journal

Blood viscosity in clinical practice: A critical review of diagnostic utility, therapeutic implications, and evidence gaps.

Clinical hemorheology and microcirculation·2026
Same journal

Evaluation of an oral Beta-caryophyllene Indena Phytosome<sup>®</sup> for the treatment of pain and inflammation in interstitial cystitis.

Clinical hemorheology and microcirculation·2026
See all related articles

Aging accelerates cardiovascular disease by impairing endothelial function through oxidative stress. Understanding these age-associated changes may lead to new treatments for heart conditions in older adults.

Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Molecular Biology

Background:

  • Aging is the primary risk factor for cardiovascular diseases (CVDs), the leading cause of death and disability in Western countries.
  • Cardiovascular structure and function naturally decline with age, an
  • aging process
  • that interacts with traditional risk factors.
  • Age-associated endothelial dysfunction, driven by oxidative stress, is a key factor in cardiovascular aging.

Purpose of the Study:

  • To explore the role of the aging process in cardiovascular disease development.
  • To investigate the molecular and cellular mechanisms underlying age-associated endothelial dysfunction.
  • To identify potential therapeutic strategies for age-related cardiovascular diseases.

Related Experiment Videos

Main Methods:

  • Literature review and data synthesis on aging and cardiovascular health.
  • Analysis of molecular and cellular pathways involved in endothelial function.
  • Examination of oxidative stress markers in aging cardiovascular systems.

Main Results:

  • The aging process significantly impacts cardiovascular structure and function.
  • Oxidative stress-induced endothelial dysfunction is a critical component of cardiovascular aging.
  • Age-related changes modulate the impact of traditional cardiovascular risk factors.

Conclusions:

  • The aging process is an independent determinant of cardiovascular health in the elderly.
  • Targeting age-associated endothelial dysfunction may offer novel therapeutic avenues.
  • Further research into molecular mechanisms can inform treatments for age-related heart disease.