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Updated: Jul 13, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Aging and endothelial dysfunction

Francesco Cosentino1, Elena Osto

  • 1Cardiology, 2nd Faculty of Medicine, University "La Sapienza", Rome, Italy. f_cosentino@hotmail.com

Clinical Hemorheology and Microcirculation
|July 21, 2007
PubMed

Insights

Aging accelerates cardiovascular disease by impairing endothelial function through oxidative stress. Understanding these age-associated changes may lead to new treatments for heart conditions in older adults.

Area of Science:

  • Cardiovascular Science
  • Gerontology
  • Molecular Biology

Background:

  • Aging is the primary risk factor for cardiovascular diseases (CVDs), the leading cause of death and disability in Western countries.
  • Cardiovascular structure and function naturally decline with age, an
  • aging process
  • that interacts with traditional risk factors.
  • Age-associated endothelial dysfunction, driven by oxidative stress, is a key factor in cardiovascular aging.

Purpose of the Study:

  • To explore the role of the aging process in cardiovascular disease development.
  • To investigate the molecular and cellular mechanisms underlying age-associated endothelial dysfunction.
  • To identify potential therapeutic strategies for age-related cardiovascular diseases.

Main Methods:

  • Literature review and data synthesis on aging and cardiovascular health.
  • Analysis of molecular and cellular pathways involved in endothelial function.
  • Examination of oxidative stress markers in aging cardiovascular systems.

Main Results:

  • The aging process significantly impacts cardiovascular structure and function.
  • Oxidative stress-induced endothelial dysfunction is a critical component of cardiovascular aging.
  • Age-related changes modulate the impact of traditional cardiovascular risk factors.

Conclusions:

  • The aging process is an independent determinant of cardiovascular health in the elderly.
  • Targeting age-associated endothelial dysfunction may offer novel therapeutic avenues.
  • Further research into molecular mechanisms can inform treatments for age-related heart disease.

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