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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
A decade of AIRE
Diane Mathis1, Christophe Benoist
1The Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Abstract:
In 1997, the autoimmune regulator (AIRE) gene was identified as the locus underlying susceptibility to the polyendocrine autoimmune disease known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). In the intervening 10 years, it has become increasingly clear that this rare disorder has provided us with an illuminative window on one of the most fundamental processes of the immune system--the establishment and maintenance of self tolerance.
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