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Related Concept Videos

Mechanism of Cardiac Arrhythmias01:28

Mechanism of Cardiac Arrhythmias

Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

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Related Experiment Video

Updated: Jul 13, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

[Genetics in neurocardiogenic syncope].

Małgorzata Lelonek1

  • 1Klinika Kardiologii I Katedry Kardiologii i Kardiochirurgii, Uniwersytetu Medycznego w Lodzi, Szpital Kliniczny nr 3 im. Seweryna Sterlinga. mlelonek@poczta.fm

Przeglad Lekarski
|July 24, 2007
PubMed
Summary

Vasovagal syncope, a common cause of fainting, has a significant heritable component. Molecular genetic studies are needed to understand its causes and improve patient care.

Area of Science:

  • Cardiology
  • Genetics
  • Neurology

Context:

  • Syncope is a frequent clinical issue, with vasovagal syncope being the most common type.
  • Familial descriptions of vasovagal syncope are limited, despite evidence suggesting a strong genetic influence in over 20% of cases.
  • Existing research on genetic factors primarily focuses on orthostatic hypotension and intolerance, not vasovagal syncope directly.

Purpose:

  • To highlight the scarcity of molecular genetic studies in vasovagal syncope.
  • To review existing gene polymorphism research in related conditions like orthostatic hypotension.
  • To emphasize the potential of molecular genetics in elucidating vasovagal syncope pathophysiology.

Summary:

  • Vasovagal syncope, a transient loss of consciousness, is common and often heritable.

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Last Updated: Jul 13, 2026

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Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
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  • Research has explored gene polymorphisms in related conditions, including endothelin-1, adrenergic receptors, and sodium channels.
  • Studies have also identified mitochondrial DNA mutations in families with orthostatic hypotension.

    • Impact:

    • Molecular genetic studies can advance the understanding of vasovagal syncope's underlying mechanisms.
    • Such research may lead to improved diagnostic accuracy and personalized treatment strategies.
    • Identifying genetic markers could aid in predicting individual prognosis for vasovagal syncope.