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Contractility Measurements on Isolated Papillary Muscles for the Investigation of Cardiac Inotropy in Mice
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Effect of moniliformin on myocardial contractility in rats

L L Fan1, J Li, L H Sun

  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.

Biomedical and Environmental Sciences : BES
|September 1, 1991
PubMed

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...